推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
-10 to -25°C
SMILES字符串
O=C(/C=C/C1=CN=CC=C1)NCCCCC2CCN(CC2)C(C3=CC=C(C=C3)N4CCN(CC4)CCCCCCC#CC5=CC=CC6=C5CN(C6=O)C7C(NC(CC7)=O)=O)=O
InChI
1S/C49H59N7O5/c57-45(22-16-38-12-10-26-50-35-38)51-27-7-6-11-37-24-29-55(30-25-37)48(60)40-17-19-41(20-18-40)54-33-31-53(32-34-54)28-8-4-2-1-3-5-13-39-14-9-15-42-43(39)36-56(49(42)61)44-21-23-46(58)52-47(44)59/h9-10,12,14-20,22,26,35,37,44H,1-4,6-8,11,21,
InChI key
JTTGVFCANBFLCE-CJLVFECKSA-N
生化/生理作用
Orally available, cell penetrant, potent and highly selective PROTAC that induces NAMPT degradation in several cancer cells lines
SIAIS630121 is an orally available, cell penetrant, potent and highly selective proteolysis-targeting chimera (PROTAC) that induces NAMPT (nicotinamide phosphoribosyltransferase) degradation in several cancer cells lines (SW620, HT29, and HCT116). It contains NAMPT inhibitor FK866 linked to cereblon (CRBN) ligand lenalidomide. SIAIS630121 exhibits rapid and potent degradation of iNAMPT and eNAMPT.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
Cell Chemical Biology, 29(11), 1616-1629 (2022)
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