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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O[C@@H]1[C@@]2([H])[C@](C(C=C1NC(C3=C(C=CC=C3)O)=O)=O)([H])O2
InChI
1S/C13H11NO5/c15-8-4-2-1-3-6(8)13(18)14-7-5-9(16)11-12(19-11)10(7)17/h1-5,10-12,15,17H,(H,14,18)/t10-,11+,12-/m0/s1
InChI key
IUOMATKBBPCLFR-TUAOUCFPSA-N
生化/生理作用
Potent, selective, and irreversible inhibitor of NF-κB that covalently binds to a cysteine residue.
DHMEQ is a potent, selective, and irreversible inhibitor of NF-κB that covalently binds to a cysteine residue. It inhibits inflammatory cytokine expression in mice models. DHMEQ is a potent and non/low toxic in vivo anti-inflammatory agent effective in number of animal models.
DHMEQ is a potent, selective, and irreversible inhibitor of NF-κB that covalently binds to a cysteine residue. It inhibits inflammatory cytokine expression in mice models. DHMEQ is a potent and non/low toxic in vivo anti-inflammatory agent effective in number of animal models.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Reactive oxygen species trigger NF-?B-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity
Redox Biology, 47, 102157-102157 (2021)
Jun Ma et al.
Cells, 10(9) (2021-09-29)
General inflammatory diseases include skin inflammation, rheumatoid arthritis, inflammatory bowel diseases, sepsis, arteriosclerosis, and asthma. Although these diseases have been extensively studied, most of them are still difficult to treat. Meanwhile, NF-κB is a transcription factor promoting the expression of
Dehydroxymethylepoxyquinomicin, a novel nuclear factor-?B inhibitor, prevents the development of cyclosporine A nephrotoxicity in a rat model
BMC Pharmacology & Toxicology, 21(1), 60-60 (2020)
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