所有图片(1)
别名:
2-Fluoro-1-[(3R,4R)-3-(2-pyrimidinylamino)-4-[[4-(trifluoromethyl)phenyl]methoxy]-1-pyrrolidinyl]-2-propen-1-one
经验公式（希尔记法）:
C19H18F4N4O2
推荐产品
生化/生理作用
MYF-03-176 is an orally active, potent, irreversible pan-TEAD inhibitor that disrupts YAP-TEAD association by targeting TEAD palmitate pocket for covalent binding. MYF-03-176 suppresses NCI-H226 cellular TEAD transcriptional activity (IC50 = 11 nM by TEAD reporter assay), blocking TEAD-mediated target genes expression (CTGF, CYR61, ANKRD1) and suppression (BMF). MYF-03-176 effectively inhibits Hippo signaling-driven human lung mesothelioma NCI-H226 proliferaton in cultures (IC50 = 9 nM in 5 days) and in a xenograft model in mice in vivo (35 or 75 mg/kg b.i.d. p.o. for 4 wks).
注意
Hygroscopic
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
eLife, 11, e78810-e78810 (2022)
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