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生化/生理作用
Orally available, highly potent analog of coenzyme Q10 that modulates the activity of oxidoreductases and improves cell redox status
Vatiquinone (EPI-743), a metabolite of a-tocotrienol, is an orally available and highly potent analog of coenzyme Q10 that modulates the activity of oxidoreductases including AD(P)H:quinone oxidoreductase 1, resulting in increased cellular GSH concentration and improvement in redox status. Vatiquinone is an agent designated to treat mitochondrial diseases.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
S Küpeli et al.
The Journal of urology, 141(2), 378-378 (1989-02-01)
We describe a patient with a radiopaque calculus in the vas deferens that was inappropriately diagnosed as a ureteral calculus.
Rapid identification of a novel complex I MT-ND3 m.10134C>A mutation in a Leigh syndrome patient
PLoS ONE, 9(8), e10487-e10487 (2014)
William D Shrader et al.
Bioorganic & medicinal chemistry letters, 21(12), 3693-3698 (2011-05-24)
We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial
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