所有图片(2)
别名:
(+)-(R)-IMP-1575, (+)-IMP-1575, (R)-(+)-2-(Isobutylamino)-1-(4-(6-methylpyridin-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one, (R)-1-[6,7-Dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylpropyl)amino]ethenone, (R)-IMP-1575
经验公式（希尔记法）:
C19H25N3OS
分子量:
343.49
UNSPSC代码:
12352200
NACRES:
NA.21
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
oil
颜色
, Faint yellow to yellow orange
储存温度
2-8°C
SMILES字符串
CC1=CC=CC([C@@H]2N(CCC3=C2C=CS3)C(CNCC(C)C)=O)=N1
生化/生理作用
IMP-1575 is a donor substrate Pal-CoA-competitive (Ki = 38 nM) hedgehog acyltransferase (HHAT) inhibitor with significantly higher potency than its structure analog RUSKI-201 (IC50 = 0.75 vs. 2.0 μM, respectively, by Acyl-cLIP assay).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.
Andrei SA, et al.
Methods in Molecular Biology, 2374, 13-26 (2022)
Claire E Coupland et al.
Molecular cell, 81(24), 5025-5038 (2021-12-11)
The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the
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