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主要文件

COO原产地证书/COA分析证书

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安全信息

安全和法规

SML3595

Riociguat

Name: Riociguat
Brand: SIGMA

≥98% (HPLC)

别名:

BAY 63-2521, BAY 632521, Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]methylcarbamate, N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester

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About This Item

经验公式（希尔记法）:

C₂₀H₁₉FN₈O₂

CAS号:

625115-55-1

分子量:

422.42

MDL编号:

MFCD19443708

UNSPSC代码:

12352200

NACRES:

NA.77

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Sigma-Aldrich

SML1221

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Y0002238

Riociguat

Sigma-Aldrich

D2763

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Y0001437

那格列奈

USP

1604519

Riociguat

Sigma-Aldrich

SML1070

SR-58611A

Y0000733

达卡巴嗪

Sigma-Aldrich

SML3385

Binimetinib

Sigma-Aldrich

SML2259

拉帕替尼

Sigma-Aldrich

SMB01383

PhIP

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

-10 to -25°C

SMILES字符串

NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC(N)=C1N(C(OC)=O)C

InChI

1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)

InChI key

WXXSNCNJFUAIDG-UHFFFAOYSA-N

生化/生理作用

Riociguat is a soluble guanylate cyclase stimulator in clinical trials for pulmonary hypertension. It increases cGMP production and induces pulmonary vasodilation. It has not effect on phosphodiesterases PDE1-9 and PDE11 when used a concentrations less than 3µM.