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生化/生理作用
GSK3179106 is a potent and selective gut-restricted RET (Rearranged during transfection) kinase inhibitor. GSK3179106 attenuates abdominal contractions induced by colorectal distention in rat models.
WGK
WGK 3
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Not applicable
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法规信息
新产品
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS
ACS Medicinal Chemistry Letters, 9, 623-628 (2018)
Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity
Journal of Pharmacology and Experimental Therapeutics, 368, 299-307 (2019)
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