所有图片(1)
别名:
(S)-2,2,2-trifluoro-N-(4-((3-(2-(piperidin-3-ylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)ethane-1-sulfonamide
经验公式（希尔记法）:
C26H25F3N6O3S
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=S(NC(C=C1)=C2C(C=CC=C2)=C1OC3=NC=CC=C3C4=CC=NC(N[C@@H]5CNCCC5)=N4)(CC(F)(F)F)=O
生化/生理作用
PAIR1 is a cell penetrant, potent and selective ATP-competitive partial antagonist of the IRE1α (endoplasmic reticulum to nucleus signaling 1) RNase activity, while affording quantitative kinase activity inhibition. PAIR1 partially antagonize the IRE1α RNase at full occupancy of the kinase. In β-cells PAIR1 allows adaptive splicing of Xbp1 mRNA while suppressing destructive ER mRNA endonucleolytic decay and apoptosis.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Hannah C Feldman et al.
Nature chemical biology, 17(11), 1148-1156 (2021-09-25)
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate dichotomy is promoted by differential activation of the ER transmembrane
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