推荐产品
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
N3(CCCC3)C[C@@H](NC(=O)CCCCCCCCCCCCCCC)[C@H](O)c1cc2c(cc1)OCCO2
InChI
1S/C31H52N2O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-30(34)32-27(25-33-20-15-16-21-33)31(35)26-18-19-28-29(24-26)37-23-22-36-28/h18-19,24,27,31,35H,2-17,20-23,25H2,1H3,(H,32,34)/t27-,31-/m1/s1
InChI key
BBTZZVJOQCCAOR-DLFZDVPBSA-N
生化/生理作用
Cell penetrant, potent and selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG)
EtDO-P4, a ceramide analog, is a cell penetrant, potent and selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG). Inhibition of UGCG by EtDO-P4 decreases drug resistance and enhances cytotoxicity of chemotherapeutic drugs such as vincristine, daunorubicin, Lucena-1 and cisplatin.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells
Acta Biochimica Polonica, 63 (2016)
Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor
Biochimica et Biophysica Acta, 1820 (2012)
Eduardo J Salustiano et al.
The Journal of biological chemistry, 295(19), 6457-6471 (2020-04-02)
Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane
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