SML3521
m-Trifluoromethyl-diphenyl diselenide
≥98% (HPLC)
别名:
1,2-Bis(3-(trifluoromethyl)phenyl)diselane, Bis(3-trifluoromethylphenyl) diselenide, Di(3-trifluoromethylphenyl) diselenide, TFDD, [(m-CF3-PhSe)2; Bis[3-(trifluoromethyl)phenyl] diselenide
InChI key
DGOYKERNPXVRDM-UHFFFAOYSA-N
SMILES string
FC(F)(C1=CC([Se][Se]C2=CC=CC(C(F)(F)F)=C2)=CC=C1)F
assay
≥98% (HPLC)
form
oil
color
colorless to yellow
storage temp.
-10 to -25°C
Quality Level
Biochem/physiol Actions
Brain blood barrier penetrant organoselenium compound that exhibits antinociceptive and antidepressant effects
m-Trifluoromethyl-diphenyl diselenide (TFDD) is a brain blood barrier penetrant organoselenium compound that exhibits antinociceptive and antidepressant effects in animal models without development of tolerance or withdrawal sighs. m-Trifluoromethyl-diphenyl diselenide acts as opioid system modulator, which attenuates morphine withdrawal signs in mice. It exhibits antioxidant and anti-inflammatory properties which might contribute to neuro protective effects.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Carolina C Martins et al.
Progress in neuro-psychopharmacology & biological psychiatry, 98, 109803-109803 (2019-11-07)
The opioid withdrawal syndrome is defined as a complex phenomenon involving multiple cellular adaptations, which leads to the emergence of aversive physical and affective signs. The m-trifluoromethyl-diphenyl diselenide (m-CF3-PhSe)2 elicits an antidepressant-like effect by modulating the opioid system in different
Cleisson Schossler Garcia et al.
Molecular neurobiology, 58(10), 5078-5089 (2021-07-11)
Chronic pain and depression often coexist sharing common pathological mechanisms, and available analgesics and antidepressants have demonstrated limited clinical efficacy. Evidence has demonstrated that neuronal oxidative stress, apoptosis, and also glucocorticoid receptor dysregulation facilitate the occurrence and development of both
Contribution of Opioid and Nitrergic Systems to m-Trifluoromethyl diphenyl Diselenide Attenuates Morphine-Induced Tolerance in Mice
ACS Chemical Neuroscience, 13(7), 910-919 (2022)
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