所有图片(1)
别名:
2-(4-Fluorophenyl)-1H-indene-1,3(2H)-dione, 2-(4-Fluorophenyl)indene-1,3-dione
经验公式（希尔记法）:
C15H9FO2
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1C2=C(C(C1C3=CC=C(C=C3)F)=O)C=CC=C2
InChI
1S/C15H9FO2/c16-10-7-5-9(6-8-10)13-14(17)11-3-1-2-4-12(11)15(13)18/h1-8,13H
InChI key
NASXCEITKQITLD-UHFFFAOYSA-N
生化/生理作用
Fluindione is an orally active vitamin K antagonist (VKA) that exerts its in vivo anticoagulant efficacy by inhibiting the vitamin K epoxide reductase activity (VKOR IC50 = 6.6 nM) in a substrate-comeptitive manner.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Role of ABC transporters in trans-epithelial transport of vitamin K antagonists
Bernadette Espana , Caroline Prouillac
Biopharmaceutics & Drug Disposition, 38, 20-32 (2017)
Antithrombotic efficacy of the vitamin K antagonist fluindione in a human Ex vivo model of arterial thrombosis : effect of anticoagulation level and combination therapy with aspirin
Bossavy JP, Sakariassen KS, Thalamas C, Boneu B, Cadroy Y
Arteriosclerosis, Thrombosis, and Vascular Biology, 19, 2269-2275 (1999)
Xuejie Chen et al.
Blood, 132(18), 1974-1984 (2018-08-10)
Warfarin, acenocoumarol, phenprocoumon, and fluindione are commonly prescribed oral anticoagulants for the prevention and treatment of thromboembolic disorders. These anticoagulants function by impairing the biosynthesis of active vitamin K-dependent coagulation factors through the inhibition of vitamin K epoxide reductase (VKOR).
Jonaz Font et al.
Fundamental & clinical pharmacology, 32(4), 378-391 (2018-03-12)
Whether oral anticoagulants, vitamin K antagonists (VKAs), and nonvitamin K oral anticoagulant (NOACs) frequently prescribed to atrial fibrillation (AF) patients, do themselves have a pro- or anti-arrhythmic effect have never been addressed. Transmembrane action potentials were recorded in an acute
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门