所有图片(1)
别名:
2-(1H-1,2,4-Triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-4H-1-benzopyran-4-one
经验公式（希尔记法）:
C18H10F3N3O2
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1C(C2=CC=C(C=C2)C(F)(F)F)=C(OC3=CC=CC=C13)N4N=CN=C4
生化/生理作用
Chromenone 1 is a bone morphogenetic protein (BMP) signaling potentiator that exerts its effect via negative TGFβ feedback loops, independent of direct kinase inhibition. Chromenone 1 prevents cardiogenesis induction by 0.5 μM BMP inhibitor DMH1 (IC50 = 200 nM; mESC-Myh6-GFP) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts (ALP activity induction EC50 = 340 nM; E100% and Emax = induction by 7.5 and 50 ng/mL BMP-4, respectively).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators
Journal of Medicinal Chemistry, 65 (2022)
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