所有图片(1)
别名:
(ADH-1)c trifluoroacetate, Cyclic-N-Ac-CHAVC-NH2 trifluoroacetate, Cyclic-N-Ac-Cys-His-Ala-Val-Cys-NH2 trifluoroacetate, Exherin trifluoroacetate, N-Ac-CHAVC-NH2 (C1-C5 disulfide) trifluoroacetate, N-Ac-CHAVC-NH2 trifluoroacetate, N-Ac-Cys-His-Ala-Val-Cys-NH2 (Cys1-Cys5 disulfide) trifluoroacetate, c(N-Ac-CHAVC-NH2) trifluoroacetate, c(N-Ac-Cys-His-Ala-Val-Cys-NH2) trifluoroacetate
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质量水平
检测方案
≥95% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to off-white
储存温度
−20°C
InChI
1S/C22H34N8O6S2/c1-10(2)17-22(36)29-15(18(23)32)7-37-38-8-16(27-12(4)31)21(35)28-14(5-13-6-24-9-25-13)20(34)26-11(3)19(33)30-17/h6,9-11,14-17H,5,7-8H2,1-4H3,(H2,23,32)(H,24,25)(H,26,34)(H,27,31)(H,28,35)(H,29,36)(H,30,33)/t11-,14-,15-,16-,17-/m0/s1
InChI key
FQVLRGLGWNWPSS-BXBUPLCLSA-N
生化/生理作用
ADH-1 is an N-cadherin (CD325; NCAD) antagonist that selectively inhibits NCAD-dependent neurite outgrowth (IC50 = 323 μM; PN1-2 rat cerebral neurons on monolayer of chick NCAD-expressing 3T3), while exhibiting no effect against integrin receptor-dependent neurite outgrowth. ADH-1 inhibits NCAD-mediated signaling events in cultures (0.2-2.5 mg/mL) and exhibits anti-tumor efficacy in vivo (50-100 mg/kg i.p. in rats and mice).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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