SML3461
Exatecan mesylate
≥98% (HPLC)
别名:
(1S,9S)-9-Ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-1-amine methanesulfonate, DX8951f
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C24H22FN3O4· CH3SO3H
CAS号:
分子量:
531.55
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
-10 to -25°C
SMILES字符串
O=C1N2C(C3=NC4=CC(F)=C(C(CC[C@@H]5N)=C4C5=C3C2)C)=CC6=C1COC([C@@]6(CC)O)=O.OS(=O)(C)=O
InChI
1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H3,(H,2,3,4)/t16-,24-;/m0./s1
InChI key
BICYDYDJHSBMFS-GRGFAMGGSA-N
生化/生理作用
Exatecan mesylate is a water soluble camptothecin (CPT) analog that exhibits a stronger topoisomerase-I inhibitory and antitumor activities and is highly effective against P-glycoprotein (P-gp) mediated multi-drug resistant cells. Several of the exatecan derivative based antibody-drug and peptide-drug conjugate payloads display high therapeutic indices universally across solid tumors.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Oral - Muta. 1B - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ghassan K Abou-Alfa et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24(27), 4441-4447 (2006-09-20)
Exatecan mesylate is a hexacyclic, water-soluble, topoisomerase-1 inhibitor. Exatecan has single-agent and combination activity with gemcitabine in advanced pancreatic cancer. A multicenter, randomized, phase III trial comparing exatecan plus gemcitabine versus gemcitabine alone in advanced pancreatic cancer was conducted. Eligibility
Jie Chen et al.
Molecular medicine reports, 19(1), 477-489 (2018-11-16)
Unresectable advanced pancreatic cancer (APC) is a highly lethal malignancy. Although numerous chemotherapeutic regimens are available, evidence regarding the survival extension, the life quality improvement, the associated risks and occurrence rates of adverse effects, is required. The effects of 19
N Joto et al.
International journal of cancer, 72(4), 680-686 (1997-08-07)
We previously reported that DX-8951f, a novel water-soluble camptothecin analog, significantly inhibits the growth of various human and murine tumors in vitro and in vivo. The antitumor effects and topoisomerase I inhibitory activity of DX-8951f are stronger than those of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门