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质量水平
方案
≥97% (HPLC)
表单
powder
颜色
, White to very dark gray
溶解性
DMSO: 2 mg/mL, clear
储存温度
-10 to -25°C
SMILES字符串
Nc1cnc(cc1)Oc2ccc(cc2)C(C)(C)C
InChI
1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
InChI key
WHIWGRCYMQLLAO-UHFFFAOYSA-N
生化/生理作用
CB-103 is an orally active Notch transcription activation inhibitor that targets RBPJ-Notch intracellular domain (NICD) transcription complex assembly. CB-103 exhibits antiproliferation efficacy against Notch-driven cancer growth in cultures (IC50 from 50 nM to 3 μM; patient-derived T-ALL cells positive for N1-ICD) and in tumor models in vivo (10-25 mg/kg qd or bid p.o. to mice with human T-ALL xenografts).
Orally active Notch transcription activation inhibitor with anti-cancer efficacy in cultures and in vivo.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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