所有图片(1)
别名:
1,1-Bis(3′-indolyl)-1-(p-hydroxyphenyl)methane, 4-(Di-1H-indol-3-ylmethyl)phenol; (4-Hydroxyphenyl)bis(1H-indol-3-yl)methane, 7,7-Bis(3-indolyl)-p-cresol, C-DIM 8, CDIM8
经验公式（希尔记法）:
C23H18N2O
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
off-white to pink
溶解性
DMSO: 2 mg/mL
储存温度
−20°C
SMILES字符串
OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
生化/生理作用
DIM-C-pPhOH is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhOH decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231breast cancer cells. DIM-C-pPhOH inhibits migration of Rh30 and MDA-MB-231 cancer cells.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Alexandra Lacey et al.
Cancer research, 77(3), 732-741 (2016-11-20)
Alveolar rhabdomyosarcoma (ARMS) is a devastating pediatric disease driven by expression of the oncogenic fusion gene PAX3-FOXO1A. In this study, we report overexpression of the nuclear receptor NR4A1 in rhabdomyosarcomas that is sufficient to drive high expression of PAX3-FOXO1A there.
Kumaravel Mohankumar et al.
Endocrinology, 161(4) (2020-02-27)
Endometriosis is an inflammatory disease that primarily affects women during their reproductive years, and since current hormonal therapies are of concern, new hormone-independent treatment regimens are needed. The orphan nuclear receptor 4A1 (NR4A1, Nur77) is expressed in patient-derived (stromal) endometriotic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门