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质量水平
方案
≥95% (HPLC)
表单
(Powder or Lyophilized powder or film)
储存条件
desiccated
颜色
white to beige
储存温度
-10 to -25°C
SMILES字符串
OC([C@@H](N)C)=O.OC(CC[C@H](N)C(O)=O)=O.NCCCC[C@H](N)C(O)=O.OC([C@@H](N)CC1=CC=C(C=C1)O)=O
InChI
1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1
InChI key
YLOCGHYTXIINAI-XKUOMLDTSA-N
生化/生理作用
Glatiramer acetate, a myelin basic protein mimetic, is an immunomodulator used for treatment of Multiple Sclerosis. Glatiramer acetate is a mixture of synthetic peptides randomly composed of glutamic acid, lysine, alanine, and tyrosine. It reduces relapse rate and disease progression in Multiple Sclerosis. Its mechanism of action is not fully understood. Glatiramer acetate generates anti-inflammatory Th2 cells, which produce neurotrophic factors.
Myelin basic protein mimetic; immunodmodulator; used to treat multiple sclerosis; generates anti-inflammatory Th2 cells, which produce neurotrophic factors; promotes neurogenesis
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Glatiramer acetate attenuates depressive/anxiety-like behaviors and cognitive deficits induced by post-weaning social isolation in male mice
Sanusi Andah Salihu , Homanaz Ghafari ,Narges K Gortany
Psychopharmacology, 238, 2121-2132 (2021)
Synthetic Cationic Autoantigen Mimics Glatiramer Acetate Persistence at the Site of Injection and Is Efficacious Against Experimental Autoimmune Encephalomyelitis
Song JY, Griffin JD, Larson NR, Christopher MA, Middaugh CR, Berkland CJ
Frontiers in Immunology, 11, 603029-603029 (2021)
Effects of methylprednisolone and glatiramer acetate on nitric oxide formation of cytokine-stimulated cells from the rat oligodendroglial cell line OLN-93
Christian Holzknecht
Neuroimmunomodulation, 17, 23-30 (2010)
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