SML3338
NF-56-EJ40
≥98% (HPLC)
别名:
2-(2-(4′-((4-Methylpiperazin-1-yl)methyl)biphenyl-3-ylcarboxamido)phenyl)acetic acid, 2-(2-(4′-((4-methylpiperazin-1-yl)methyl)-[1,1′-biphenyl]-3-carboxamido)phenyl)acetic acid, 2-[[[4′-[(4-Methyl-1-piperazinyl)methyl][1,1′-biphenyl]-3-yl]carbonyl]amino]-benzeneacetic acid
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About This Item
生化/生理作用
NF-56-EJ40 is a high-affinity, potent and human species-selective succinate receptor SUCNR1 (GPR91) antagonist (human GPR91 Ki/KD = 17.4/33 nM; GTPγS assay IC50 = 25 nM/human, >100 μM/rat). Extracellular succinate is reported to hyperpolarize M2 macrophages through GPR91-mediated Gq signaling, blockable by NF-56-EJ40 (1 μM) or Gq inhibitor YM-254890 (1 μM).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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