所有图片(1)
别名:
(2S,4R)-1-((S)-2-(9-(4-((4-(5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylbenzyl)amino)butanamido)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
经验公式（希尔记法）:
C58H74FN9O5S
分子量:
1028.33
UNSPSC代码:
12352200
NACRES:
NA.32
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质量水平
检测方案
≥98% (HPLC)
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC1=C(C(C)=CC(CNCCCC(NCCCCCCCCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C=C3)C4=C(N=CS4)C)C)=O)=O)C(C)(C)C)=O)=O)=C1)C5=C(N(C=N5)C)C6=CC=NC7=C6C=CC(F)=C7
生化/生理作用
MS9715 is a potent and highly selective degrader (PROTAC) of NSD3 (Nuclear receptor binding SET domain protein 3) that effectively depletes NSD3 and the associated cMyc oncogenic node. MS9715 comprised of NSD3 antagonist BI-9321 linked to an E3 ligase VHL ligand. It potently inhibits growth of NSD3-dependent hematological cancer cells.
WGK
WGK 3
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