所有图片(1)
别名:
4-(4-(2-Bromoacetamido)butyl)benzoic acid, 4-[4-[(Bromoacetyl)amino]butyl]benzoic acid, KRAS Agonist-533, NSC 112533, NSC112533, p-[4-(2-Bromoacetamido)butyl]benzoic acid
经验公式（希尔记法）:
C13H16BrNO3
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1
InChI
1S/C13H16BrNO3/c14-9-12(16)15-8-2-1-3-10-4-6-11(7-5-10)13(17)18/h4-7H,1-3,8-9H2,(H,15,16)(H,17,18)
InChI key
WZQJLTLURXNPQG-UHFFFAOYSA-N
生化/生理作用
KRA-333 is a potent and selective KRAS agonist that binds directly to the GTP/GDP binding pocket of KRAS preventing the cleavage of GTP into GDP and caucusing accumulation of activated GTP-KRAS and suppression of cell growth. KRA-333 promotes apoptosis and autophagic cell death of cancer cells and inhibits growth of mutant KRAS lung cancer in xenografts mice model.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
Xu K, Park D, Magis AT, Zhang J, Zhou W, Sica GL, Ramalingam SS, Curran WJ, Deng X
Molecular Cancer, 18 (2019)
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