所有图片(1)
别名:
2-Cyclobutyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione
经验公式（希尔记法）:
C22H19N3O2
推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear (Warmed)
储存温度
-10 to -25°C
SMILES字符串
O=C1N(C2=CC=CC=C2)C(C3CCC3)=NC4=C1C(C5=CC=CC=C5N4C)=O
生化/生理作用
SRI-41315 is a cell penetrant and potent readthrough agents that suppress translation termination at premature termination codon and allows translation elongation to continue in the correct reading frame and generate a full-length protein. SRI-41315 induces the translational pause that occurs at premature termination codons by depleting eRF1 protein levels through a proteasome-mediated degradation pathway. SRI-41315 restores CFTR expression and function in in immortalized and primary human bronchial epithelial cells.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Jyoti Sharma et al.
Nature communications, 12(1), 4358-4358 (2021-07-18)
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of current readthrough agents prompted us
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