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主要文件

COO原产地证书/COA分析证书

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安全信息

安全和法规

SML3310

DN02

Name: DN02
Brand: SIGMA

≥98% (HPLC)

别名:

4-(4-((3-Aminoazetidin-1-yl)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one

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About This Item

经验公式（希尔记法）:

C₂₂H₂₄FN₃O₃

分子量:

397.44

UNSPSC代码:

12352200

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

-10 to -25°C

生化/生理作用

DN02 is a potent and selective BRD8 first bromodomain inhibitor (BRD8(1) IC50 = 48 nM, BRD4(1) & BRD9 IC50 ≥10 μM; Kd = 34 nM/BRD8(1), >1 μM/BRD8(2), CBP, p300) that serves as a useful chemical probe for the selective engagement of BRD8 and enrichment of native NuA4 complexes.