推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
[S]1(=O)(=O)CC(CC1)N(CC(C)(C)C)C(=O)CCl
InChI
1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3
InChI key
NMHVAHHYKGXBMY-UHFFFAOYSA-N
生化/生理作用
In vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1)
Sulfopin is an in vivo active, highly potent, and selective covalent inhibitor of the peptidyl-prolyl isomerase NIMA-interacting-1 (Pin1) that binds to active site Cys113. Sulfopin induces downregulation of c-Myc target genes, inhibits tumor progression. It extends survival in murine and zebrafish models of MYCN-driven neuroblastoma, and in a murine model of pancreatic cancer.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Christian Dubiella et al.
Nature chemical biology, 17(9), 954-963 (2021-05-12)
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library to identify covalent inhibitors targeting Pin1's active
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