质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O[C@H]1[C@@](N2C(NC(C=C2)=O)=O)([H])O[C@@]3([H])[C@@]1([H])OP(OC3)(O[Na])=O
InChI
1S/C9H11N2O8P.Na/c12-5-1-2-11(9(14)10-5)8-6(13)7-4(18-8)3-17-20(15,16)19-7;/h1-2,4,6-8,13H,3H2,(H,15,16)(H,10,12,14);/q;+1/p-1
InChI key
APYWIKXPIFYSBG-UHFFFAOYSA-M
一般描述
3’,5’-cyclic uridine monophosphate (cUMP) is a cyclic pyrimidine nucleotide. cUMP (3’,5’-cyclic uridine monophosphate) sodium salt is a secondary messenger functioning in bacterial immunity against viruses.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sander de Kivit et al.
Nature metabolism, 2(10), 1046-1061 (2020-09-23)
Following activation, conventional T (Tconv) cells undergo an mTOR-driven glycolytic switch. Regulatory T (Treg) cells reportedly repress the mTOR pathway and avoid glycolysis. However, here we demonstrate that human thymus-derived Treg (tTreg) cells can become glycolytic in response to tumour
Nicole Blaquiere et al.
Journal of medicinal chemistry, 61(15), 6801-6813 (2018-06-26)
NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation, secondary lymphoid organ development, and
Jieqiong Zhang et al.
Cell reports, 27(9), 2679-2689 (2019-05-30)
Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling and substrates such as receptor interacting protein kinase 1 (RIPK1) to promote cell survival. We investigate how these functions contribute to
Weisong Duan et al.
Molecular neurobiology, 58(5), 2435-2446 (2021-01-14)
TANK-binding kinase1 (TBK1) haploinsufficiency has been shown to cause both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD); however, the mechanism is unclear. Myeloid Tbk1 knockout mice (Tbk1-LKO mice) were established and motor function and pathological analyses were also performed.
Hans D Brightbill et al.
Nature communications, 9(1), 179-179 (2018-01-14)
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that experimental lupus in NZB/W F1 mice
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