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Merck
CN
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主要文件

安全信息

SML3276

Sigma-Aldrich

Apelin-17 trifluoroacetate salt

≥95% (HPLC)

别名:

Apelin 17 trifluoroacetate salt, K17F trifluoroacetate salt, L-Lysyl-L-phenylalanyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine trifluoroacetate salt, Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe

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About This Item

UNSPSC代码:
12352202
NACRES:
NA.77
方案:
≥95% (HPLC)
表单:
powder

质量水平

100

方案

≥95% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to off-white

储存温度

−20°C

生化/生理作用

Apelin-17 (K17F) is a potent and selective endogenous agonist of apelin receptor (apelin-R). Apelin-17 has 16 times higher affinity for apelin-R than apelin-13 (pE13F) (Ki = 0.05 versus 0.8 nM).
potent and selective endogenous agonist of apelin receptor (apelin-R)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000184641
0000184642
0000179960
0000184641
0000184642

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Adrien Flahault et al.
Nature communications, 12(1), 305-305 (2021-01-14)
Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R) with LIT01-196, a metabolically stable apelin-17 analog, may be beneficial for treating the Syndrome of Inappropriate Antidiuresis, in which AVP hypersecretion
Wang Wang et al.
Hypertension (Dallas, Tex. : 1979), 68(2), 365-377 (2016-05-25)
Apelin peptides mediate beneficial effects on the cardiovascular system and are being targeted as potential new drugs. However, apelin peptides have extremely short biological half-lives, and improved understanding of apelin peptide metabolism may lead to the discovery of biologically stable

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