所有图片(1)
别名:
B 992, Dichloro[7,12-diethyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-stannate(2-) (OC-6-13)-dihydrogen, SnMP, Stanate, Tin mesoporphyrin
经验公式（希尔记法）:
C34H36Cl2N4O4Sn
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
, Faint brown to dark red
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
CC1=C(CCC(O)=O)/C2=C/C3=N/C(C(C)=C3CCC(O)=O)=C\C4=C(CC)C(C)=C(/C=C5N=C(C(C)=C\5CC)/C=C1\N26)N4[Sn]6(Cl)Cl
InChI
1S/C34H38N4O4.2ClH.Sn/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;;/h13-16H,7-12H2,1-6H3,(H4,35,36,37,38,39,40,41,42);2*1H;/q;;;+4/p-4/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;;
InChI key
LLDZJTIZVZFNCM-UHEVNVKKSA-J
生化/生理作用
Stannsoporfin is a potent inhibitor of heme oxygenase 1 (HO-1) and heme oxygenase 2 (HO-2). It inhibits hepatic HO and controls serum levels of bilirubin in infants. Stannsoporfin potently inhibits myeloid HO-1 in tumors. It inhibits immune suppression of chemotherapy-elicited CD8+ T cells. Stannsoporfin concurrently administer with 5-Fluoro uracil produces immediate tumor regression in mice model of breast tumor.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Jatin Tulsulkar et al.
Brain research, 1662, 1-6 (2017-02-22)
A gender difference in stroke is observed throughout epidemiologic studies, pathophysiology, treatment and outcomes. We investigated the neuroprotective role of hemeoxygenase (HO) enzyme, which catabolizes free heme to bilirubin, carbon monoxide and biliverdin in the female brain after permanent ischemia.
Yoshiro Onoue et al.
Circulation journal : official journal of the Japanese Circulation Society, 82(11), 2905-2912 (2018-08-14)
Resistance exercise has beneficial effects for patients with peripheral arterial diseases. The hypothesis that muscle growth promotes angiogenesis by interacting with neighboring cells in ischemic lesions was assessed. Methods and Results: Skeletal muscle-specific inducible Akt1 transgenic (Akt1-TG) mice that induce growth of
Tamara Muliaditan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(7), 1617-1628 (2018-01-18)
Purpose: Unprecedented clinical outcomes have been achieved in a variety of cancers by targeting immune checkpoint molecules. This preclinical study investigates heme oxygenase-1 (HO-1), an immunosuppressive enzyme that is expressed in a wide variety of cancers, as a potential immune
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