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Merck
CN
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文件

SML3252

Sigma-Aldrich

SF3B1 Protein Degrader

≥95% (HPLC)

别名:

2-((4-chlorophenyl)amino)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)thiazole-4-carboxamide, O4I2-based PROTAC® degrader

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About This Item

经验公式（希尔记法）:
C29H29ClN6O5S
分子量:
609.10
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

powder

储存条件

under inert gas

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

O=C1N(C(C2=C1C=CC=C2NCCCCCCNC(C3=CSC(NC4=CC=C(C=C4)Cl)=N3)=O)=O)C5CCC(NC5=O)=O

生化/生理作用

SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model.

法律信息

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Rodrigo A Gama-Brambila et al.
Cell chemical biology, 28(11), 1616-1627 (2021-05-29)
The proteolysis-targeting chimeras (PROTACs) are a new technology to degrade target proteins. However, their clinical application is limited currently by lack of chemical binders to target proteins. For instance, it is still unknown whether splicing factor 3B subunit 1 (SF3B1)

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