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Merck
CN
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主要文件

安全信息

SML3233

Sigma-Aldrich

GlucoseCy5

≥98% (HPLC)

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About This Item

经验公式(希尔记法):
C38H50N3O6Cl
分子量:
680.27
UNSPSC代码:
12352107
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

blue to black

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

一般描述

GlucoseCy5 is a cell-permeable, Cy5-linked 1-amino-1-deoxy-β-glucose fluorescent tracer. It is used for glucose transporter (GLUT)-mediated molecular sensing and bioimaging. GlucoseCy5 demonstrates superior specificity, sensitivity, and non-toxicity over 2-NBDG. λ emission & excitation ~ 644 nm & 665 nm. Suggested optimum concentration and incubation for cellular uptake: 50 μM & 20 min.

应用

GlucoseCy5 has been used as a component in serum-free Dulbecco′s modified eagle medium (DMEM) for fluorescence-activated cell sorting (FACS) and glucose-uptake assay.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
Zhang X, et al.
Cell Reports (2023)
Hu Xu et al.
Biochemical and biophysical research communications, 474(2), 240-246 (2016-04-02)
Two novel cyanine-based 1-amino-1-deoxy-β-glucose conjugates (Glu-1N-Cy3 and Glu-1N-Cy5) were designed, synthesized and their fluorescence characteristics were studied. Both Glu-1N-Cy3 and Glu-1N-Cy5 accumulate in living HT29 human colon cancer cells, which overexpress glucose transporters (GLUTs). The cellular uptake of the bioprobes
McLane J Watson et al.
Nature, 591(7851), 645-651 (2021-02-17)
Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells1,2. Tumour cells show deregulated metabolism, leading to a metabolite-depleted
Xiangyin Liu et al.
Biochemical and biophysical research communications, 480(3), 341-347 (2016-10-26)
Two novel fluorescent bioprobes, namely, 6N-Gly-Cy3 and 6N-Gly-Cy5, were designed and synthesized for real-time glucose transport imaging as well as potentially useful tracer for galactokinase metabolism. The structure of the bioprobes was fully characterized by 1H NMR, 13C NMR, IR
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
Watson MJ, et al.
Nature (2021)

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