推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
ClC1=CC=CC=C1[C@@H](CCC(O)=O)CNC(C2=C(C)C(N3CCCC3)=NC4=CC=C(Br)C=C42)=O.Cl.O
InChI
1S/C26H27BrClN3O3.ClH.H2O/c1-16-24(20-14-18(27)9-10-22(20)30-25(16)31-12-4-5-13-31)26(34)29-15-17(8-11-23(32)33)19-6-2-3-7-21(19)28;;/h2-3,6-7,9-10,14,17H,4-5,8,11-13,15H2,1H3,(H,29,34)(H,32,33);1H;1H2/t17-;;/m0../s1
InChI key
GGGPATBQZZPKRC-RMRYJAPISA-N
生化/生理作用
BAY-6672 is an orally active, potent and selective prostaglandin F receptor (FP-R, PTGFR) antagonist (IC50 = 11 nM against 3 nM PGF2?-induced calcium flux in hFP-R Chem-1 cells; IC50 = 12/18 nM against 3 μM PGF2α-induced KC/MCP1 production in NIH-3T3) with >420-fold selectivity over human prostaglandin receptors (PG-Rs) EP1-4, DP, CRTH2 and IP. BAY-6672 shows in vivo efficacy in a murine lung fibrosis model (3, 10, 30 mg/kg b.i.d. p.o.).
Orally active, potent and selective prostaglandin F receptor (FP-R, PTGFR) antagonist with in vivo efficacy in a murine lung fibrosis model.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hartmut Beck et al.
Journal of medicinal chemistry, 63(20), 11639-11662 (2020-09-25)
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF remains high. The human prostaglandin
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门