SML3216

Melarsoprol

Name: Melarsoprol
Brand: SIGMA

≥98% (HPLC), Apoptosis inducer, powder

别名:

(2-(4-(4,6-diamino-1,3,5-triazin-2-ylamino)phenyl)-1,3,2-dithiarsolan-4-yl)methanol, 2-(4-melamin-2-ylphenyl)-4-hydroxymethyl-1,3-dithia-2-arsolane, 2-p-(4,6-diamino-s-triazin-2-ylamino)phenyl-4-hydroxymethyl-1,3,2-dithiarsoline, Mel B, Melarsaprol, Melarsen B, RP 3854, p-[(4,6-diamino-s-triazin-2-yl)amino]dithiobenzenearsonous acid 3-hydroxypropylene ester

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₅AsN₆OS₂

化学文摘社编号:

494-79-1

分子量:

398.34

NACRES:

NA.77

UNSPSC Code:

12352107

MDL number:

MFCD00866803

主要文件

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产品名称

Melarsoprol, ≥98% (HPLC)

InChI key

JCYZMTMYPZHVBF-UHFFFAOYSA-N

SMILES string

NC1=NC(N)=NC(NC2=CC=C(C=C2)[As]3SCC(S3)CO)=N1

InChI

1S/C12H15AsN6OS2/c14-10-17-11(15)19-12(18-10)16-8-3-1-7(2-4-8)13-21-6-9(5-20)22-13/h1-4,9,20H,5-6H2,(H5,14,15,16,17,18,19)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

An antiprotozoal (Trypanosoma) drug used in treatment of trypanosomiasis (Chagas disease and West African sleeping sickness);

Melarsoprol is an antiprotozoal (Trypanosoma) drug used in treatment of trypanosomiasis (Chagas disease and West African sleeping sickness). The drug mechanism of action is not well characterized. Melarsoprol is still the only effective drug for chemotherapy of second stage of T. b. rhodesiense sleeping sickness. As other arsenic-containing compounds melarsoprol causes cell apoptosis of myeloma and other cancer cell lines.