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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O=S(C)(CCC#N)=O
InChI key
LQFRYKBDZNPJSW-UHFFFAOYSA-N
生化/生理作用
Dapansutrile is an orally active, specific and potent inhibitor of NLRP3 inflammasome activation that decreases IL-1β and IL-18 release. Dapansutrile exhibits no effect on NLRC4 and AIM2 inflammasomes activation. It appears that Dapansutrile directly interact with NLRP3. It does not show hematological, or organ toxicities in humans at oral doses up to 1,000 mg/day
orally active, specific and potent inhibitor of NLRP3 inflammasome activation; anti-inflammatory
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
Journal of Cardiovascular Pharmacology, 73(4), 215-222 (2019)
NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis
Arthritis Research & Therapy, 20(1), 169-169 (2018)
OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation
Proceedings of the National Academy of Sciences of the USA, 115(7), E1530-E1539 (2018)
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