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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML3199

Monomethyl Auristatin E

Name: Monomethyl Auristatin E
Brand: SIGMA

≥98%

别名:

MMAE, MMAE toxin, Monomethylauristatin E, N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

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About This Item

经验公式（希尔记法）:

C₃₉H₆₇N₅O₇

CAS号:

474645-27-7

分子量:

717.98

UNSPSC代码:

12352200

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SML0974

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SML0586

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Sigma-Aldrich

5.04314

硼替佐米

质量水平

100

方案

≥98%

表单

film or powder

颜色

white to off-white

储存温度

−20°C

SMILES字符串

N1([C@@H](CCC1)[C@H](OC)[C@@H](C)C(=O)N[C@@H]([C@@H](O)c2ccccc2)C)C(=O)C[C@@H](OC)[C@@H](N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C)[C@H](CC)C

InChI

1S/C39H67N5O7/c1-13-25(6)34(43(10)39(49)33(24(4)5)42-38(48)32(40-9)23(2)3)30(50-11)22-31(45)44-21-17-20-29(44)36(51-12)26(7)37(47)41-27(8)35(46)28-18-15-14-16-19-28/h14-16,18-19,23-27,29-30,32-36,40,46H,13,17,20-22H2,1-12H3,(H,41,47)(H,42,48)/t25-,26+,27+,29-,30+,32-,33-,34-,35+,36+/m0/s1

InChI key

DASWEROEPLKSEI-UIJRFTGLSA-N

生化/生理作用

Monomethyl Auristatin E (MMAE) is a highly potent peptidyl antimitotic agent that blocks the polymerization of tubulin. Monomethyl Auristatin E is a component of a clinically approved antibodydirected conjugates Brentuximab vedotin, Glembatumumab vedotin, Enfortumab vedotin and Polatuzumab vedotin.

highly potent antimitotic agent; anti-tubulin agent;