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COO原产地证书/COA分析证书

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SML3188

Isavuconazonium sulfate

Name: Isavuconazonium sulfate
Brand: SIGMA

≥95% (HPLC)

别名:

(2-{[(1-{1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1H-1,2,4-triazol-4-ium-4-yl}ethoxy)carbonyl](methyl)amino}pyridin-3-yl)methyl N-methylglycinate hydrogen sulfate, BAL 8557-002, BAL8557

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About This Item

经验公式（希尔记法）:

C₃₅H₃₅F₂N₈O₅S · SO₄H

CAS号:

946075-13-4

分子量:

814.84

MDL编号:

MFCD27987905

UNSPSC代码:

51111800

NACRES:

NA.77

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尼洛替尼

质量水平

100

方案

≥95% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES字符串

O=S(O)([O-])=O.N#CC(C=C1)=CC=C1C2=CSC([C@H](C)[C@](O)(CN3C=[N+](C(C)OC(N(C)C4=NC=CC=C4COC(CNC)=O)=O)C=N3)C5=CC(F)=CC=C5F)=N2

InChI

1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1

InChI key

LWXUIUUOMSMZKJ-KLFWAVJMSA-M

生化/生理作用

Isavuconazonium sulfate (BAL8557) is a prodrug of isavuconazole (BAL 4815), a triazole antifungal drug. Isavuconazole inhibits fungal sterol biosynthesis by inhibition of cytochrome P450 sterol 14-α-demethylase (CYP51), an enzyme in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Isavuconazonium sulfate has been approved for the treatment of both invasive aspergillosis and invasive mucormycosis.