SML3181
7,8-Dimethoxyperphenazine
≥98% (HPLC)
别名:
2-(4-(3-((3-chlorophenyl)(3,4-dimethoxyphenyl)amino)propyl)piperazin-1-yl)ethan-1-ol, 4-[3-[8-Chloro-2,3-dimethoxy-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol
产品名称
7,8-Dimethoxyperphenazine, ≥98% (HPLC)
InChI key
GKWVWOUUPIERSK-UHFFFAOYSA-N
SMILES string
ClC1=CC=C2C(N(CCCN3CCN(CCO)CC3)C(C=C(C(OC)=C4)OC)=C4S2)=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
7,8-Dimethoxyperphenazine is a cell penetrant inhibitor of UHM (U2AF homology motif) -ULM (U2AF ligand motif) interactions that interacts with the tryptophan binding pocket of different UHM domains including SPF45, PUF60 and U2AF. 7,8-Dimethoxyperphenazine inhibits early spliceosome assembly on pre-mRNA substrates in vitro.
cell penetrant inhibitor of UHM (U2AF homology motif) -ULM (U2AF ligand motif) interactions that interacts with the tryptophan binding pocket of UHM domains
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
Pravin Kumar Ankush Jagtap et al.
Nature communications, 11(1), 5621-5621 (2020-11-08)
Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM interactions mediate heterodimerization of the constitutive splicing factors U2AF65 and U2AF35 and between other splicing factors
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