推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
oil
颜色
, Colorless to light yellow
储存温度
-10 to -25°C
SMILES字符串
O[C@H]1CC(N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O)(OP(OC[C@H]4OC(O)[C@H](O)[C@@H]4O)(O)=O)=O
生化/生理作用
2′-Deoxyadenosine 5′-diphosphoribose (2′- deoxy-ADPR) is a superagonist of the TRPM2 channel (transient receptor potential melastatin 2), a Ca2+-permeable, voltage independent, nonselective cation channel implicated in free-radical induced cell death, chemotaxis, insulin secretion, thermosensation, immune cell responses and activation of the inflammasome. 2′-Deoxy-ADPR caused 10.4-fold higher whole-cell currents at saturation than adenosine diphosphoribose (ADPR), which had been previously considered to be the main intracellular second messenger that activated TRPM2. 2′-Deoxy-ADPR decreased the inactivation rate resulting in higher average open probability.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist
Nature Chemical Biology, 13(9), 1036-1044 (2017)
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