SML3155
Brincidofovir
≥98% (HPLC)
别名:
3-(Hexadecyloxy)propyl hydrogen ((S)-1-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxypropan-2-yloxy)methylphosphonate, CMX 001, CMX001, Hexadecyloxypropyl-cidofovir
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About This Item
经验公式（希尔记法）:
C27H52N3O7P
CAS号:
分子量:
561.69
MDL编号:
UNSPSC代码:
51111800
UNSPSC代码:
12352200
NACRES:
NA.77
生化/生理作用
Brincidofovir is an orally bioavailable prodrug of cidofovir with activity against pox viruses as well as CMV, HSV, and Varicella zoster.
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Carc. 2 - Repr. 2 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
R Anthony Vere Hodge et al.
Advances in pharmacology (San Diego, Calif.), 67, 1-38 (2013-07-28)
This review starts with a brief description of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), the clinical diseases they cause, and the continuing clinical need for antiviral chemotherapy. A historical overview describes the progress from the early
Erik De Clercq
Medicinal research reviews, 33(6), 1249-1277 (2013-03-16)
Prominent in the current stage of antiviral drug development are: (i) for human immunodeficiency virus (HIV), the use of fixed-dose combinations (FDCs), the most recent example being Stribild(TM); (ii) for hepatitis C virus (HCV), the pleiade of direct-acting antivirals (DAAs)
Julio J Alvarez-Cardona et al.
Future microbiology, 15, 389-400 (2020-03-14)
Brincidofovir (BCV) is a lipid conjugate of cidofovir with good oral bioavailability, enabling optimal intracellular levels of the active drug. Lower rates of nephrotoxicity and myelotoxicity make it a favorable alternative. Despite a greater safety profile among pediatric hematopoietic cell transplant
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