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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
储存温度
2-8°C
SMILES字符串
O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(F)=C(NC(C)=O)C(O[C@H](C3=CC=CC=C3)C)=C2
InChI
1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18-,19-/m0/s1
InChI key
FRBRZGLUFOZRGD-JVPBZIDWSA-N
一般描述
GSK046 is an orally bioavailable small molecule. Its structure contains a poly-substituted phenyl ring in the center. GSK046 reduces immuno-inflammation by inhibiting the production of monocyte chemoattractant protein 1 (MCP-1), a chemokine involved in the regulation of macrophage activation.
生化/生理作用
potent and highly selective inhibitor of bromodomain BD2 of BRD2, BDR3, BRD4, BRDT
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins
Fu Y, et al.
European Journal of Medicinal Chemistry (2021)
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