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主要文件

COO原产地证书/COA分析证书

安全信息

安全和法规

SML3059

Lacosamide

Name: Lacosamide
Brand: SIGMA

≥98% (HPLC)

别名:

(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide, ADD 243037, ADD-243037, ADD243037, Erlosamide, LCM, SPM-927, SPM927

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About This Item

经验公式（希尔记法）:

C₁₃H₁₈N₂O₃

CAS号:

175481-36-4

分子量:

250.29

UNSPSC代码:

12352200

NACRES:

NA.77

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Y0001982

Lacosamide

Sigma-Aldrich

5.08508

Zonisamide

Sigma-Aldrich

L8668

左乙拉西坦

Sigma-Aldrich

L3791

拉莫三嗪

Supelco

L-029

Lacosamide solution

USP

1357158

拉科酰胺S-对映体

USP

1357103

Lacosamide CV

Sigma-Aldrich

C8414

Clobazam

Sigma-Aldrich

B5435

BIA 2-093

Y0001973

Lacosamide for system suitability

质量水平

100

方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D 13 to 18° (C=0.5g/100mL, MeOH)

药品控制

USDEA Schedule V

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

N([C@H](COC)C(=O)NCc1ccccc1)C(=O)C

InChI

1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1

InChI key

VPPJLAIAVCUEMN-GFCCVEGCSA-N

生化/生理作用

Lacosamide is an orally active anticonvulsant that blocks voltage-gated sodium channels (VGSCs) selectively in their inactivated state (IC50 = 16 μM/Nav1.8, 182 μM/Nav1.7, 415 μM/Nav1.3) over resting state by enhancing slow inactivation. In addition to in vivo anticonvulsant activity (ED50 = 4.5 mg/kg in mice via i.p., 3.9 mg/kg in rats via p.o. by maximal electroshock seizure test), lacosamide also shows therapeutic efficacy in various pain models (10-30 mg/kg in rats via i.p.).