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Merck
CN

SML3050

Sigma-Aldrich

Olsalazine sodium

别名:

Olsalazine sodium, 3,3´-Azobis(6-hydroxybenzoic acid) sodium, 5,5′-Azodisalicylic acid sodium, 5,5′-azobis(salicylic acid) sodium, C.I. Mordant Yellow 5; 3,3′-dicarboxy-4,4′-dihydroxyazobenzene sodium, azodisal sodium

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About This Item

经验公式(希尔记法):
C14H8N2O6 · 2Na
CAS号:
分子量:
346.20
UNSPSC代码:
12352200
NACRES:
NA.24

检测方案

≥98% (HPLC)

质量水平

形式

powder

颜色

white to beige

溶解性

H2O: 2 mg/mL, clear

储存温度

2-8°C

生化/生理作用

Olsalazine is an anti-inflammatory drug used in inflammatory bowel disease and ulcerative colitis treatments. It is a pro-drug of 5-aminosalicylic acid (mesalamine) that it is converted by the bacteria in the colon to mesalamine. Olsalazine (5-aminosalicylic acid) is consider as a broad-spectrum anticancer agent. Additionally, olsalazine increases both eEF1A2 and utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Amany A Abdin et al.
Journal of Crohn's & colitis, 2(4), 296-303 (2008-12-01)
Traditional medical treatments for ulcerative colitis (UC) are still compromised by its adverse effects and not potent enough to keep in remission for long-term periods. So, new therapies that are targeted at specific disease mechanisms have the potential to provide
Sandra Cortez-Maya et al.
Biomolecules, 9(8) (2019-08-16)
Improving the activity and selectivity profile of anticancer agents will require designing drug carrier systems that employ soluble macromolecules. Olsalazine-PAMAM-dendrimer-salicylic acid-conjugates with dendritic arms of different lengths have shown good stability regarding the chemical link between drug and spacer. In

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