SML3044
XL177A
≥98% (HPLC)
别名:
(S)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide, 3-Acridinecarboxamide, 9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-
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About This Item
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1N(CC2(O)CCN(C([C@H](CC3=CC=CC=C3)CCCNC(C4=CC(N=C(CCCC5)C5=C6Cl)=C6C=C4)=O)=O)CC2)C=NC7=CC(NC(CCN8CCN(C)CC8)=O)=CC=C71
InChI key
UYJWYMWIVMCGQZ-DHUJRADRSA-N
生化/生理作用
XL177A is a cell penetrant, potent and highly selective covalent inhibitor of the deubiquitinating enzyme USP7 that binds to catalytic cysteine C223.
cell penetrant, potent and highly selective covalent inhibitor of the deubiquitinating enzyme USP7
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
Nathan J Schauer et al.
Scientific reports, 10(1), 5324-5324 (2020-03-27)
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific protein substrates in order to alter their degradation rate and sub-cellular localization. USP7 has been proposed as a therapeutic target in several cancers because
Jonathan W Bushman et al.
Cell chemical biology, 28(1), 78-87 (2020-10-03)
Deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin, thereby reversing the activity of E3 ubiquitin ligases and are central to the control of protein abundance and function. Despite the growing interest in DUBs as therapeutic targets, cellular functions for DUBs
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