所有图片(1)
别名:
N-Cycloheptyl-?-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]-benzeneacetamide
经验公式（希尔记法）:
C19H27N3OS
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(C(C1=CC=CC=C1)SC2=NCCN2C)NC3CCCCCC3
生化/生理作用
Apostatin-1 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. Apostatin-1 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently Apostatin-1 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Daichao Xu et al.
Nature, 587(7832), 133-138 (2020-09-25)
Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathological state. Although mechanisms of cell death have been thoroughly
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