生化/生理作用
SBI-425 is an orally available, potent and selective inhibitor of TNAP (tissue-nonspecific alkaline phosphase).
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Campbell R Sheen et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 824-836 (2014-11-28)
Medial vascular calcification (MVC) is a pathological phenomenon that causes vascular stiffening and can lead to heart failure; it is common to a variety of conditions, including aging, chronic kidney disease, diabetes, obesity, and a variety of rare genetic diseases.
Filippo Romanelli et al.
PloS one, 12(10), e0186426-e0186426 (2017-10-13)
Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelium leads to arterial calcification in mice. The purpose of this study was to examine the effect of elevated endothelial TNAP on coronary atherosclerosis. In addition, we aimed to examine endogenous TNAP activity
Anthony B Pinkerton et al.
Bioorganic & medicinal chemistry letters, 28(1), 31-34 (2017-11-28)
Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePPi), a potent mineralization inhibitor, to phosphate (Pi). By the controlled hydrolysis of ePPi, TNAP maintains the correct ratio of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门