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安全信息

SML2912

Sigma-Aldrich

UNC4976 Trifluoroacetate

≥95% (HPLC)

别名:

Methyl N6-(bicyclo[2.2.1]heptan-2-yl)-N2-(4-(tert-butyl)benzoyl)-L-phenylalanyl-L-alanyl-L-leucyl-N6-methyl-L-lysyl-L-serinate trifluoroacetate

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1 KIT
¥7,268.37

¥7,268.37


预计发货时间2025年4月17日详情



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1 KIT
¥7,268.37

About This Item

经验公式(希尔记法):
C47H70N6O8 · xC2HF3O2
分子量:
847.09 (free base basis)
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77

¥7,268.37


预计发货时间2025年4月17日详情


质量水平

方案

≥95% (HPLC)

表单

film

颜色

white to beige

运输

wet ice

储存温度

−20°C

SMILES字符串

N([C@@H](CO)C(=O)OC)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c4ccc(cc4)C(C)(C)C)Cc3ccccc3)C)CC(C)C)CCCCN(C1C2CC(C1)CC2)C

InChI key

UKWNWTBRKZUHGX-GKUWNYOMSA-N

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separation technique

mixed mode, reversed phase

separation technique

mixed mode, reversed phase

separation technique

mixed mode, reversed phase

separation technique

mixed mode, reversed phase

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

agency

suitable for USP L109

agency

suitable for USP L109

agency

suitable for USP L109

agency

suitable for USP L109

technique(s)

HPLC: suitable, UHPLC-MS: suitable, LC/MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

product line

Supel

product line

Supel

product line

Supel

product line

Supel

生化/生理作用

UNC4976 is a cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain of polycomb repressive complex 1 that enhances CBX7 chromodomain affinity for nucleic acids. UNC4976 substantially potentiates the expression of polycomb target genes.
cell penetrant and potent positive allosteric modulator (PAM) of CBX7 chromodomain

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

  • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    Kelsey N Lamb et al.
    Cell chemical biology, 26(10), 1365-1379 (2019-08-20)
    Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methyl-lysine reader

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