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Merck
CN
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主要文件

安全信息

SML2899

Sigma-Aldrich

Humanin Trifluoroacetate

≥95% (HPLC)

别名:

L-Methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-?-glutamyl-L-isoleucyl-L-?-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-L-alanine trifluoroacetate, MAPRGFSCLLLLTSEIDLPVKRRA trifluoroacetate, Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

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About This Item

经验公式（希尔记法）:
C119H204N34O32S2 · xC2HF3O2
分子量:
2687.23 (free base basis)
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

100

方案

≥95% (HPLC)

表单

lyophilized powder

颜色

white to beige

储存温度

−20°C

生化/生理作用

Humanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000167011
0000167011
0000103258

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Daniel L Morris et al.
The Journal of biological chemistry, 294(50), 19055-19065 (2019-11-07)
The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2-associated X apoptosis regulator (BAX) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing
Sandra Cristina Zárate et al.
Frontiers in aging neuroscience, 11, 123-123 (2019-06-20)
Astroglial cells are crucial for central nervous system (CNS) homeostasis. They undergo complex morpho-functional changes during aging and in response to hormonal milieu. Ovarian hormones positively affect different astroglia parameters, including regulation of cell morphology and release of neurotrophic and
Y Hashimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(11), 6336-6341 (2001-05-24)
Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Abeta amyloid, without effect on

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