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![毛喉素，7-脱乙酰基-7-[O-（N-甲基哌嗪基）-γ-丁酰基]-二盐酸盐 Chemically-modified forskolin with greater stability and water solubility than the parent compound.](/deepweb/assets/sigmaaldrich/product/images/426/701/6836ea5a-750e-4c4d-8e6e-ecf6aed4c506/640/6836ea5a-750e-4c4d-8e6e-ecf6aed4c506.jpg)
质量水平
检测方案
≥95% (HPLC)
形式
powder
旋光性
[α]/D -8 to -5°, c = 0.5 in chloroform-d
颜色
white to beige
溶解性
DMF:H2O (9:1): 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
InChI
1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
InChI key
CLOQVZCSBYBUPB-VDCUXWMXSA-N
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生化/生理作用
Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Dermal
WGK
WGK 3
法规信息
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