SML2795
IMP-1700
≥98% (HPLC)
别名:
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-3-quinolinecarboxylic acid, 1-Cyclopropyl-6-fluoro-4-oxo-7-(4-((4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
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About This Item
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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
OC(C1=CN(C2CC2)C(C=C(N3CCN(C(NC4=CC=C(C=C4)C(F)(F)F)=S)CC3)C(F)=C5)=C5C1=O)=O
InChI key
DMUZWIXJZNKJPP-UHFFFAOYSA-N
生化/生理作用
IMP-1700 is a cell-active and potent inhibitor of bacterial DNA repair that inhibits the bacterial SOS-response to DNA damage. IMP-1700 targets AddAB/RecBCD repair complex and potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.
Inhibitor of bacterial DNA repair
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
Carine S Q Lim et al.
Bioorganic & medicinal chemistry, 27(20), 114962-114962 (2019-07-17)
The global emergence of antibiotic resistance is one of the most serious challenges facing modern medicine. There is an urgent need for validation of new drug targets and the development of small molecules with novel mechanisms of action. We therefore
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