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Merck
CN
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安全信息

SML2762

Sigma-Aldrich

RG1534

≥98% (HPLC)

别名:

2-Amino-N-((4-((5-chloropyrimidin-2-yl)oxy)-3-methylphenyl)carbamoyl)benzamide, 2-Amino-N-[[[4-[(5-chloro-2-pyrimidinyl)oxy]-3-methylphenyl]amino]carbonyl]benzamide;

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About This Item

经验公式（希尔记法）:
C19H16ClN5O3
CAS号:
150096-77-8
分子量:
397.82
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

NC1=CC=CC=C1C(NC(NC2=CC(C)=C(C=C2)OC3=NC=C(C=N3)Cl)=O)=O

InChI

1S/C19H16ClN5O3/c1-11-8-13(6-7-16(11)28-19-22-9-12(20)10-23-19)24-18(27)25-17(26)14-4-2-3-5-15(14)21/h2-10H,21H2,1H3,(H2,24,25,26,27)

InChI key

NLVSCQFSPVSAOF-UHFFFAOYSA-N

生化/生理作用

RG1534 is an inhibitor of hTERT promoter activity that selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT) that downregulates hTERT expression. RG1534 induces mitochondrial defects, oxidative stress, DNA damage and apoptosis in cancer cell while sparing normal cells
inhibitor of hTERT promoter activity that selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000104438
0000104439
0000097626

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Jin H Song et al.
Cell chemical biology, 26(8), 1110-1121 (2019-06-04)
Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided clinical benefit. Here we report that, instead of targeting the telomerase enzyme directly, small molecules that bind

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