SML2722
MU140
≥98% (HPLC)
别名:
1-Methyl-4-(9-(2-phenyl-phenyl)-7-oxa-2-aza-bicyclo[4.3.0]nona-1,3,5,8-tetraen-3-yl)-1H-pyrazole, 3-(Biphenyl-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)furo[3,2-b]pyridine, 3-[1,1′-Biphenyl]-2-yl-5-(1-methyl-1H-pyrazol-4-yl)-furo[3,2-b]pyridine, MU1210 inactive control, MU1210 negative control, VN270, VN339 inactive control, VN339 negative control
产品名称
MU140, ≥98% (HPLC)
InChI key
QSBNKGGRYOLZND-UHFFFAOYSA-N
SMILES string
CN(N=C1)C=C1C2=CC=C(OC=C3C4=C(C5=CC=CC=C5)C=CC=C4)C3=N2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Inactive (negative) control for the cdc-like kinase (cdc2-like kinase) CLK1, CLK2, CLK4, and homeodomain-interacting protein kinase 2 (HIPK2) inhibitor MU1210.
MU140 is a structure analog of and the recommended inactive (negative) control for MU1210, an inhibitor against cdc-like kinase (cdc2-like kinase) CLK1, CLK2, CLK4, and homeodomain-interacting protein kinase 2 (HIPK2). MU140 exhibits no inhbitory potency toward CLK1/2/3/4, DYRK1a/1b/2 or HIPK1/2/3 (IC50 >3 μM).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Václav Němec et al.
Angewandte Chemie (International ed. in English), 58(4), 1062-1066 (2018-12-21)
Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic
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