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方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
[nH]1nc(cc1Nc2nc(nc4[nH]ccc42)N3C[C@H](NCC3)C(C)C)C(C)(C)C
InChI
1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)/t14-/m0/s1
InChI key
HNOLTAKAPDKZRY-AWEZNQCLSA-N
生化/生理作用
Spastazoline is a cell penetrant, potent and selective ATP-competitive inhibitor of spastin.
cell penetrant, potent and selective ATP-competitive inhibitor of spastin
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
历史批次信息供参考:
Rudolf Pisa et al.
Journal of the American Chemical Society, 141(14), 5602-5606 (2019-03-16)
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structural data for inhibitor-protein complexes
Tommaso Cupido et al.
Nature chemical biology, 15(5), 444-452 (2019-02-20)
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellular processes. To design a chemical inhibitor of
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