所有图片(1)
别名:
α-[（2-氯乙酰基）（3-氯-4-甲氧基苯基）氨基]-N-（2-苯乙基）-2-噻吩乙酰胺, 2-氯-N-（3-氯-4-甲氧基苯基）-N-（2-氧代-2-（苯乙基氨基）-1-（噻吩-2-基）乙基）乙酰胺, BRD-5421, BRD5421, CID 3689413, ML 162, ML-162, 分子库162
经验公式（希尔记法）:
C23H22Cl2N2O3S
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检测方案
≥98% (HPLC)
形式
powder
颜色
white to very dark brown
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
生化/生理作用
ML162是一种小分子，可通过共价抑制细胞磷脂谷胱甘肽过氧化物酶（GPx-4；GPx4；GSHPx-4；PHGPx；SNGPx；snPHGPx）诱导铁死亡。癌症培养物中的合成致死性研究确定了诸如HRas（G12V）表达和富马酸水合酶（FH）缺失对ML162敏感性的影响因子（在BJeLR-HRas（G12V）&UOK262-FH-/-培养物中IC50分别为25 nM & 35 nM）。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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